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β Cell–specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity

The islet in type 2 diabetes (T2D) shares many features of the brain in protein misfolding diseases. There is a deficit of β cells with islet amyloid derived from islet amyloid polypeptide (IAPP), a protein coexpressed with insulin. Small intracellular membrane-permeant oligomers, the most toxic for...

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Dades bibliogràfiques
Publicat a:JCI Insight
Autors principals: Gurlo, Tatyana, Costes, Safia, Hoang, Jonathan D., Rivera, Jacqueline F., Butler, Alexandra E., Butler, Peter C.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5085608/
https://ncbi.nlm.nih.gov/pubmed/27812546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89590
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