β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency

OBJECTIVE: The islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP). Toxic oligomers of IAPP form intracellularly in β-cells in humans with type 2 diabetes, suggesting impaired cle...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Costes, Safia, Huang, Chang-jiang, Gurlo, Tatyana, Daval, Marie, Matveyenko, Aleksey V., Rizza, Robert A., Butler, Alexandra E., Butler, Peter C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Diabetes Association 2011
Gaiak:
Islet Studies
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012175/
https://ncbi.nlm.nih.gov/pubmed/20980462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0522
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