Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With Metformin

OBJECTIVE: We sought to establish the extent and mechanisms by which sitagliptin and metformin singly and in combination modify islet disease progression in human islet amyloid polypeptide transgenic (HIP) rats, a model for type 2 diabetes. RESEARCH DESIGN AND METHODS: HIP rats were treated with sit...

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Detalhes bibliográficos
Main Authors: Matveyenko, Aleksey V., Dry, Sarah, Cox, Heather I., Moshtaghian, Artemis, Gurlo, Tatyana, Galasso, Ryan, Butler, Alexandra E., Butler, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699878/
https://ncbi.nlm.nih.gov/pubmed/19403868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0058
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