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Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity
Type 2 diabetes (T2D) is characterized by a deficiency in β cell mass, increased β cell apoptosis, and extracellular accumulation of islet amyloid derived from islet amyloid polypeptide (IAPP), which β cells coexpress with insulin. IAPP expression is increased in the context of insulin resistance, t...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Society for Clinical Investigation
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4109537/ https://ncbi.nlm.nih.gov/pubmed/25036708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71981 |
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