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Autophagy defends pancreatic β cells from human islet amyloid polypeptide-induced toxicity

Type 2 diabetes (T2D) is characterized by a deficiency in β cell mass, increased β cell apoptosis, and extracellular accumulation of islet amyloid derived from islet amyloid polypeptide (IAPP), which β cells coexpress with insulin. IAPP expression is increased in the context of insulin resistance, t...

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Bibliografiske detaljer
Main Authors: Rivera, Jacqueline F., Costes, Safia, Gurlo, Tatyana, Glabe, Charles G., Butler, Peter C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4109537/
https://ncbi.nlm.nih.gov/pubmed/25036708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI71981
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