Evidence for Proteotoxicity in β Cells in Type 2 Diabetes : Toxic Islet Amyloid Polypeptide Oligomers Form Intracellularly in the Secretory Pathway

The islet in type 2 diabetes mellitus (T2DM) is characterized by a deficit in β cells and islet amyloid derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β cells. It is increasingly appreciated that the toxic form of amyloidogenic proteins is not amyloid but small...

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Main Authors: Gurlo, Tatyana, Ryazantsev, Sergey, Huang, Chang-jiang, Yeh, Michael W., Reber, Howard A., Hines, O. Joe, O'Brien, Timothy D., Glabe, Charles G., Butler, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2010
Assuntos:
Regular Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2808091/
https://ncbi.nlm.nih.gov/pubmed/20042670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2010.090532
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