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Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis

Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin secretion, loss of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted with insulin by pancreat...

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Hlavní autoři: Haataja, Leena, Gurlo, Tatyana, Huang, Chang J., Butler, Peter C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Endocrine Society 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2528855/
https://ncbi.nlm.nih.gov/pubmed/18314421
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/er.2007-0037
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