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Islet Amyloid in Type 2 Diabetes, and the Toxic Oligomer Hypothesis
Type 2 diabetes (T2DM) is characterized by insulin resistance, defective insulin secretion, loss of β-cell mass with increased β-cell apoptosis and islet amyloid. The islet amyloid is derived from islet amyloid polypeptide (IAPP, amylin), a protein coexpressed and cosecreted with insulin by pancreat...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Endocrine Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2528855/ https://ncbi.nlm.nih.gov/pubmed/18314421 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/er.2007-0037 |
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