β-Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide–Induced UCH-L1 Deficiency

OBJECTIVE: The islet in type 2 diabetes is characterized by β-cell apoptosis, β-cell endoplasmic reticulum stress, and islet amyloid deposits derived from islet amyloid polypeptide (IAPP). Toxic oligomers of IAPP form intracellularly in β-cells in humans with type 2 diabetes, suggesting impaired cle...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Costes, Safia, Huang, Chang-jiang, Gurlo, Tatyana, Daval, Marie, Matveyenko, Aleksey V., Rizza, Robert A., Butler, Alexandra E., Butler, Peter C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2011
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3012175/
https://ncbi.nlm.nih.gov/pubmed/20980462
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-0522
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados