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β Cell–specific increased expression of calpastatin prevents diabetes induced by islet amyloid polypeptide toxicity
The islet in type 2 diabetes (T2D) shares many features of the brain in protein misfolding diseases. There is a deficit of β cells with islet amyloid derived from islet amyloid polypeptide (IAPP), a protein coexpressed with insulin. Small intracellular membrane-permeant oligomers, the most toxic for...
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| Publicado en: | JCI Insight |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Society for Clinical Investigation
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5085608/ https://ncbi.nlm.nih.gov/pubmed/27812546 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.89590 |
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