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Overexpression of apolipoprotein AII in transgenic mice converts high density lipoproteins to proinflammatory particles.

Previous studies showed that transgenic mice overexpressing either apolipoprotein AI (apoAI) or apolipoprotein AII (apoAII), the major proteins of HDL, exhibited elevated levels of HDL cholesterol, but, whereas the apoAI-transgenic mice were protected against atherosclerosis, the apoAII-transgenic m...

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Publicat a:J Clin Invest
Autors principals: Castellani, L W, Navab, M, Van Lenten, B J, Hedrick, C C, Hama, S Y, Goto, A M, Fogelman, A M, Lusis, A J
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 1997
Matèries:
Accés en línia:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC508211/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9218525/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI119554
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