Goblet Cell Hyperplasia Requires High Bicarbonate Transport To Support Mucin Release

Goblet cell hyperplasia, a feature of asthma and other respiratory diseases, is driven by the Th-2 cytokines IL-4 and IL-13. In human bronchial epithelial cells, we find that IL-4 induces the expression of many genes coding for ion channels and transporters, including TMEM16A, SLC26A4, SLC12A2, and...

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Publicat a:Sci Rep
Autors principals: Gorrieri, Giulia, Scudieri, Paolo, Caci, Emanuela, Schiavon, Marco, Tomati, Valeria, Sirci, Francesco, Napolitano, Francesco, Carrella, Diego, Gianotti, Ambra, Musante, Ilaria, Favia, Maria, Casavola, Valeria, Guerra, Lorenzo, Rea, Federico, Ravazzolo, Roberto, Di Bernardo, Diego, Galietta, Luis J. V.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5081536/
https://ncbi.nlm.nih.gov/pubmed/27786259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36016
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