Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine.

Production of live attenuated oral poliomyelitis vaccine (OPV) requires rigorous neurovirulence safety testing of each vaccine lot, currently carried out in monkeys. It has been reported that a change from 472-U to 472-C in the type 3 OPV RNA is associated with an increased histologic lesion score p...

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Dades bibliogràfiques

Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Chumakov, K M, Powers, L B, Noonan, K E, Roninson, I B, Levenbook, I S
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1991
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50777/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1846038/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.1.199
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