Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine.

Production of live attenuated oral poliomyelitis vaccine (OPV) requires rigorous neurovirulence safety testing of each vaccine lot, currently carried out in monkeys. It has been reported that a change from 472-U to 472-C in the type 3 OPV RNA is associated with an increased histologic lesion score p...

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Bibliographic Details

Published in:	Proc Natl Acad Sci U S A
Main Authors:	Chumakov, K M, Powers, L B, Noonan, K E, Roninson, I B, Levenbook, I S
Format:	Artigo
Language:	Inglês
Published:	National Academy of Sciences 1991
Subjects:	Research Article
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC50777/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1846038/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.1.199
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