Correlation between amount of virus with altered nucleotide sequence and the monkey test for acceptability of oral poliovirus vaccine.

Production of live attenuated oral poliomyelitis vaccine (OPV) requires rigorous neurovirulence safety testing of each vaccine lot, currently carried out in monkeys. It has been reported that a change from 472-U to 472-C in the type 3 OPV RNA is associated with an increased histologic lesion score p...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Chumakov, K M, Powers, L B, Noonan, K E, Roninson, I B, Levenbook, I S
Format: Artigo
Langue:Inglês
Publié: 1991
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC50777/
https://ncbi.nlm.nih.gov/pubmed/1846038
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