Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin and Glutathione Dependent Metabolism

The current study determined if depletion of glutathione (GSH) and inhibition of thioredoxin reductase (TR) activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol dependent oxidative stress. Buthionine sulfoximine (BSO), a GSH synthesis inhibitor;...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Radiat Res
Autors principals: Rodman, Samuel N., Spence, Jacquelyn M., Ronnfeldt, Tyler J., Zhu, Yueming, Solst, Shane R., O’Neill, Rebecca A., Allen, Bryan G., Guan, Xiangming, Spitz, Douglas R., Fath, Melissa A.
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077643/
https://ncbi.nlm.nih.gov/pubmed/27643875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR14463.1
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars