Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSS...

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Bibliografski detalji
Glavni autori: Simons, Andrean L., Parsons, Arlene D., Foster, Katherine A., Orcutt, Kevin P., Fath, Melissa A., Spitz, Douglas R.
Format: Artigo
Jezik:Inglês
Izdano: Hindawi Publishing Corporation 2009
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738856/
https://ncbi.nlm.nih.gov/pubmed/19746172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/519563
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