Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSS...

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Detalhes bibliográficos
Main Authors: Simons, Andrean L., Parsons, Arlene D., Foster, Katherine A., Orcutt, Kevin P., Fath, Melissa A., Spitz, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738856/
https://ncbi.nlm.nih.gov/pubmed/19746172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/519563
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