Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSS...

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Bibliographic Details
Main Authors: Simons, Andrean L., Parsons, Arlene D., Foster, Katherine A., Orcutt, Kevin P., Fath, Melissa A., Spitz, Douglas R.
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738856/
https://ncbi.nlm.nih.gov/pubmed/19746172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/519563
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