Cisplatin combined with Zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol dependent mechanism

Oxidative stress and mitochondrial dysfunction in cancer cells represent features that may be exploited therapeutically. We determined if agents which induce mitochondrial dysfunction such as zidovudine (AZT) and cisplatin (CIS) could enhance killing of human head and neck cancer cells via oxidative...

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Detalhes bibliográficos
Main Authors: Mattson, David M., Ahmad, Iman M., Dayal, Disha, Parsons, Arlene D., Aykin-Burns, Nukhet, Li, Ling, Orcutt, Kevin P., Spitz, Douglas R., Dornfeld, Kenneth J., Simons, Andrean L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659778/
https://ncbi.nlm.nih.gov/pubmed/18983911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.10.023
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