Cisplatin combined with Zidovudine enhances cytotoxicity and oxidative stress in human head and neck cancer cells via a thiol dependent mechanism

Oxidative stress and mitochondrial dysfunction in cancer cells represent features that may be exploited therapeutically. We determined if agents which induce mitochondrial dysfunction such as zidovudine (AZT) and cisplatin (CIS) could enhance killing of human head and neck cancer cells via oxidative...

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Main Authors: Mattson, David M., Ahmad, Iman M., Dayal, Disha, Parsons, Arlene D., Aykin-Burns, Nukhet, Li, Ling, Orcutt, Kevin P., Spitz, Douglas R., Dornfeld, Kenneth J., Simons, Andrean L.
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659778/
https://ncbi.nlm.nih.gov/pubmed/18983911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2008.10.023
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