Inhibition of Glutathione and Thioredoxin Metabolism Enhances Sensitivity to Perifosine in Head and Neck Cancer Cells

The hypothesis that the Akt inhibitor, perifosine (PER), combined with inhibitors of glutathione (GSH) and thioredoxin (Trx) metabolism will induce cytotoxicity via metabolic oxidative stress in human head and neck cancer (HNSCC) cells was tested. PER induced increases in glutathione disulfide (%GSS...

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Autors principals: Simons, Andrean L., Parsons, Arlene D., Foster, Katherine A., Orcutt, Kevin P., Fath, Melissa A., Spitz, Douglas R.
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2009
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738856/
https://ncbi.nlm.nih.gov/pubmed/19746172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/519563
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