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Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism

PURPOSE: Cancer cells (relative to normal cells) demonstrate increased steady-state levels of hydroperoxides that are compensated for by increased glucose and hydroperoxide metabolism. The current study determined if inhibitors of glucose and hydroperoxide metabolism could induce chemo-radio-sensiti...

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Detalhes bibliográficos
Main Authors: Fath, Melissa A., Ahmad, Iman M., Smith, Carmen J., Spence, Jacquelyn, Spitz, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3186854/
https://ncbi.nlm.nih.gov/pubmed/21844013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0736
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