Susceptibility of Human Head and Neck Cancer Cells to Combined Inhibition of Glutathione and Thioredoxin Metabolism

Increased glutathione (GSH) and thioredoxin (Trx) metabolism are mechanisms that are widely implicated in resistance of cancer cells to chemotherapy. The current study determined if simultaneous inhibition of GSH and Trx metabolism enhanced cell killing of human head and neck squamous cell carcinoma...

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Main Authors: Sobhakumari, Arya, Love-Homan, Laurie, Fletcher, Elise V. M., Martin, Sean M., Parsons, Arlene D., Spitz, Douglas R., Knudson, C. Michael, Simons, Andrean L.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3485193/
https://ncbi.nlm.nih.gov/pubmed/23118946
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0048175
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