NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells

Most head and neck squamous cell carcinomas (HNSCC) overexpress epidermal growth factor receptor (EGFR) and EGFR inhibitors are routinely used in the treatment of HNSCC. However, many HNSCC tumors do not respond or become refractory to EGFR inhibitors. Autophagy, which is a stress-induced cellular s...

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Détails bibliographiques
Auteurs principaux: Sobhakumari, Arya, Schickling, Brandon M., Love-Homan, Laurie, Raeburn, Ayanna, Fletcher, Elise V.M., Case, Adam J., Domann, Frederick E., Miller, Francis J., Simons, Andrean L.
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808873/
https://ncbi.nlm.nih.gov/pubmed/23917044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.07.013
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