NOX4 mediates cytoprotective autophagy induced by the EGFR inhibitor erlotinib in head and neck cancer cells

Most head and neck squamous cell carcinomas (HNSCC) overexpress epidermal growth factor receptor (EGFR) and EGFR inhibitors are routinely used in the treatment of HNSCC. However, many HNSCC tumors do not respond or become refractory to EGFR inhibitors. Autophagy, which is a stress-induced cellular s...

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Главные авторы: Sobhakumari, Arya, Schickling, Brandon M., Love-Homan, Laurie, Raeburn, Ayanna, Fletcher, Elise V.M., Case, Adam J., Domann, Frederick E., Miller, Francis J., Simons, Andrean L.
Формат: Artigo
Язык:Inglês
Опубликовано: 2013
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3808873/
https://ncbi.nlm.nih.gov/pubmed/23917044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2013.07.013
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