Erlotinib-mediated Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress through NOX4

Redox regulation of EGFR signaling helps protect cells against oxidative stress. In this study, we investigated whether the cytotoxicity of an EGFR tyrosine kinase inhibitor, erlotinib (ERL), was mediated by induction of oxidative stress in human head and neck cancer (HNSCC) cells. ERL elicited cyto...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Orcutt, Kevin P., Parsons, Arlene D., Sibenaller, Zita A., Scarbrough, Peter M., Zhu, Yueming, Sobhakumari, Arya, Wilke, Werner W., Kalen, Amanda L., Goswami, Prabhat, Miller, Francis J., Spitz, Douglas R., Simons, Andrean L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217301/
https://ncbi.nlm.nih.gov/pubmed/21482679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3425
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados