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Erlotinib-mediated Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress through NOX4

Redox regulation of EGFR signaling helps protect cells against oxidative stress. In this study, we investigated whether the cytotoxicity of an EGFR tyrosine kinase inhibitor, erlotinib (ERL), was mediated by induction of oxidative stress in human head and neck cancer (HNSCC) cells. ERL elicited cyto...

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Bibliografiske detaljer
Main Authors: Orcutt, Kevin P., Parsons, Arlene D., Sibenaller, Zita A., Scarbrough, Peter M., Zhu, Yueming, Sobhakumari, Arya, Wilke, Werner W., Kalen, Amanda L., Goswami, Prabhat, Miller, Francis J., Spitz, Douglas R., Simons, Andrean L.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217301/
https://ncbi.nlm.nih.gov/pubmed/21482679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3425
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