Erlotinib-mediated Inhibition of EGFR Signaling Induces Metabolic Oxidative Stress through NOX4

Redox regulation of EGFR signaling helps protect cells against oxidative stress. In this study, we investigated whether the cytotoxicity of an EGFR tyrosine kinase inhibitor, erlotinib (ERL), was mediated by induction of oxidative stress in human head and neck cancer (HNSCC) cells. ERL elicited cyto...

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Main Authors: Orcutt, Kevin P., Parsons, Arlene D., Sibenaller, Zita A., Scarbrough, Peter M., Zhu, Yueming, Sobhakumari, Arya, Wilke, Werner W., Kalen, Amanda L., Goswami, Prabhat, Miller, Francis J., Spitz, Douglas R., Simons, Andrean L.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217301/
https://ncbi.nlm.nih.gov/pubmed/21482679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-10-3425
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