Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin and Glutathione Dependent Metabolism

The current study determined if depletion of glutathione (GSH) and inhibition of thioredoxin reductase (TR) activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol dependent oxidative stress. Buthionine sulfoximine (BSO), a GSH synthesis inhibitor;...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Radiat Res
Main Authors: Rodman, Samuel N., Spence, Jacquelyn M., Ronnfeldt, Tyler J., Zhu, Yueming, Solst, Shane R., O’Neill, Rebecca A., Allen, Bryan G., Guan, Xiangming, Spitz, Douglas R., Fath, Melissa A.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077643/
https://ncbi.nlm.nih.gov/pubmed/27643875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR14463.1
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker