Enhancement of Radiation Response in Breast Cancer Stem Cells by Inhibition of Thioredoxin and Glutathione Dependent Metabolism

The current study determined if depletion of glutathione (GSH) and inhibition of thioredoxin reductase (TR) activity could enhance radiation responses in human breast cancer stem cells by a mechanism involving thiol dependent oxidative stress. Buthionine sulfoximine (BSO), a GSH synthesis inhibitor;...

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Publicado no:Radiat Res
Main Authors: Rodman, Samuel N., Spence, Jacquelyn M., Ronnfeldt, Tyler J., Zhu, Yueming, Solst, Shane R., O’Neill, Rebecca A., Allen, Bryan G., Guan, Xiangming, Spitz, Douglas R., Fath, Melissa A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077643/
https://ncbi.nlm.nih.gov/pubmed/27643875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1667/RR14463.1
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