D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H(2)O(2)-mediated oxidative stress

D-penicillamine (DPEN), a copper chelator, has been used in the treatment of Wilson's disease, cystinuria, and rheumatoid arthritis. Recent evidence suggests that DPEN in combination with biologically relevant copper (Cu) concentrations generates H(2)O(2) in cancer cell cultures, but the effect...

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Bibliographic Details
Published in:Free Radic Biol Med
Main Authors: Sciegienka, Sebastian J., Solst, Shane R., Falls, Kelly C., Schoenfeld, Joshua D., Klinger, Adrienne R., Ross, Natalie L., Rodman, Samuel N., Spitz, Douglas R., Fath, Melissa A.
Format: Artigo
Language:Inglês
Published: 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495544/
https://ncbi.nlm.nih.gov/pubmed/28389407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.04.001
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