D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H(2)O(2)-mediated oxidative stress

D-penicillamine (DPEN), a copper chelator, has been used in the treatment of Wilson's disease, cystinuria, and rheumatoid arthritis. Recent evidence suggests that DPEN in combination with biologically relevant copper (Cu) concentrations generates H(2)O(2) in cancer cell cultures, but the effect...

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Библиографические подробности
Опубликовано в: :Free Radic Biol Med
Главные авторы: Sciegienka, Sebastian J., Solst, Shane R., Falls, Kelly C., Schoenfeld, Joshua D., Klinger, Adrienne R., Ross, Natalie L., Rodman, Samuel N., Spitz, Douglas R., Fath, Melissa A.
Формат: Artigo
Язык:Inglês
Опубликовано: 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495544/
https://ncbi.nlm.nih.gov/pubmed/28389407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.04.001
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