D-penicillamine combined with inhibitors of hydroperoxide metabolism enhances lung and breast cancer cell responses to radiation and carboplatin via H(2)O(2)-mediated oxidative stress

D-penicillamine (DPEN), a copper chelator, has been used in the treatment of Wilson's disease, cystinuria, and rheumatoid arthritis. Recent evidence suggests that DPEN in combination with biologically relevant copper (Cu) concentrations generates H(2)O(2) in cancer cell cultures, but the effect...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Free Radic Biol Med
Egile Nagusiak: Sciegienka, Sebastian J., Solst, Shane R., Falls, Kelly C., Schoenfeld, Joshua D., Klinger, Adrienne R., Ross, Natalie L., Rodman, Samuel N., Spitz, Douglas R., Fath, Melissa A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2017
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5495544/
https://ncbi.nlm.nih.gov/pubmed/28389407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.04.001
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