TULA-2 Protein Phosphatase Suppresses Activation of Syk through the GPVI Platelet Receptor for Collagen by Dephosphorylating Tyr(P)(346), a Regulatory Site of Syk

Protein-tyrosine phosphatase TULA-2 has been shown to regulate receptor signaling in several cell types, including platelets. Platelets are critical for maintaining vascular integrity; this function is mediated by platelet aggregation in response to recognition of the exposed basement membrane colla...

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Publicado en:J Biol Chem
Autores principales: Reppschläger, Kevin, Gosselin, Jeanne, Dangelmaier, Carol A., Thomas, Dafydd H., Carpino, Nick, McKenzie, Steven E., Kunapuli, Satya P., Tsygankov, Alexander Y.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5077183/
https://ncbi.nlm.nih.gov/pubmed/27609517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.743732
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