Tyrosine Phosphorylation on Spleen Tyrosine Kinase (Syk) Is Differentially Regulated in Human and Murine Platelets by Protein Kinase C Isoforms

Protein kinase C (PKC) isoforms differentially regulate platelet functional responses downstream of glycoprotein VI (GPVI) signaling, but the role of PKCs regulating upstream effectors such as Syk is not known. We investigated the role of PKC on Syk tyrosine phosphorylation using the pan-PKC inhibit...

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Hlavní autoři: Buitrago, Lorena, Bhavanasi, Dheeraj, Dangelmaier, Carol, Manne, Bhanu Kanth, Badolia, Rachit, Borgognone, Alessandra, Tsygankov, Alexander Y., McKenzie, Steven E., Kunapuli, Satya P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2013
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3790015/
https://ncbi.nlm.nih.gov/pubmed/23960082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.464107
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