Distinct Pathways Regulate Syk Protein Activation Downstream of Immune Tyrosine Activation Motif (ITAM) and hemITAM Receptors in Platelets

Tyrosine kinase pathways are known to play an important role in the activation of platelets. In particular, the GPVI and CLEC-2 receptors are known to activate Syk upon tyrosine phosphorylation of an immune tyrosine activation motif (ITAM) and hemITAM, respectively. However, unlike GPVI, the CLEC-2...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Manne, Bhanu Kanth, Badolia, Rachit, Dangelmaier, Carol, Eble, Johannes A., Ellmeier, Wilfried, Kahn, Mark, Kunapuli, Satya P.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4416859/
https://ncbi.nlm.nih.gov/pubmed/25767114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.629527
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