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G(q)-mediated Akt translocation to the membrane: a novel PIP(3)-independent mechanism in platelets

Akt is an important signaling molecule regulating platelet aggregation. Akt is phosphorylated after translocation to the membrane through G(i) signaling pathways by a phosphatidylinositol-3,4,5-trisphosphate (PIP(3))-dependent mechanism. However, Akt is more robustly phosphorylated by thrombin compa...

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Опубликовано в: :Blood
Главные авторы: Badolia, Rachit, Manne, Bhanu Kanth, Dangelmaier, Carol, Chernoff, Jonathan, Kunapuli, Satya P.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2015
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4281826/
https://ncbi.nlm.nih.gov/pubmed/25331114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2014-05-576306
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