Platelet-Derived Short-Chain Polyphosphates Enhance the Inactivation of Tissue Factor Pathway Inhibitor by Activated Coagulation Factor XI

INTRODUCTION: Factor (F) XI supports both normal human hemostasis and pathological thrombosis. Activated FXI (FXIa) promotes thrombin generation by enzymatic activation of FXI, FIX, FX, and FV, and inactivation of alpha tissue factor pathway inhibitor (TFPIα), in vitro. Some of these reactions are n...

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Опубликовано в: :PLoS One
Главные авторы: Puy, Cristina, Tucker, Erik I., Ivanov, Ivan S., Gailani, David, Smith, Stephanie A., Morrissey, James H., Gruber, András, McCarty, Owen J. T.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2016
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072614/
https://ncbi.nlm.nih.gov/pubmed/27764259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0165172
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