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Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development
BACKGROUND: Graft-versus-host disease (GvHD) remains the major obstacle to successful allogeneic hematopoietic stem cell transplantation, despite of the immunosuppressive regimens administered to control T cell alloreactivity. PI3K/AKT/mTOR pathway is crucial in T cell activation and function and, t...
Kaydedildi:
Yayımlandı: | J Hematol Oncol |
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Asıl Yazarlar: | , , , , , , , , , , |
Materyal Türü: | Artigo |
Dil: | Inglês |
Baskı/Yayın Bilgisi: |
BioMed Central
2016
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Konular: | |
Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5072323/ https://ncbi.nlm.nih.gov/pubmed/27765055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0343-5 |
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