Targeting of PI3K/AKT/mTOR pathway to inhibit T cell activation and prevent graft-versus-host disease development

BACKGROUND: Graft-versus-host disease (GvHD) remains the major obstacle to successful allogeneic hematopoietic stem cell transplantation, despite of the immunosuppressive regimens administered to control T cell alloreactivity. PI3K/AKT/mTOR pathway is crucial in T cell activation and function and, t...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Herrero-Sánchez, Mª Carmen, Rodríguez-Serrano, Concepción, Almeida, Julia, San Segundo, Laura, Inogés, Susana, Santos-Briz, Ángel, García-Briñón, Jesús, Corchete, Luis Antonio, San Miguel, Jesús F., del Cañizo, Consuelo, Blanco, Belén
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5072323/
https://ncbi.nlm.nih.gov/pubmed/27765055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-016-0343-5
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