High-Efficiency Transduction of Primary Human Hematopoietic Stem/Progenitor Cells by AAV6 Vectors: Strategies for Overcoming Donor-Variation and Implications in Genome Editing

We have reported that of the 10 commonly used AAV serotype vectors, AAV6 is the most efficient in transducing primary human hematopoietic stem/progenitor cells (HSPCs). However, the transduction efficiency of the wild-type (WT) AAV6 vector varies greatly in HSPCs from different donors. Here we repor...

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Publicado no:Sci Rep
Main Authors: Ling, Chen, Bhukhai, Kanit, Yin, Zifei, Tan, Mengqun, Yoder, Mervin C., Leboulch, Philippe, Payen, Emmanuel, Srivastava, Arun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5069717/
https://ncbi.nlm.nih.gov/pubmed/27759036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep35495
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