High-Efficiency Transduction of Primary Human Hematopoietic Stem Cells and Erythroid Lineage-Restricted Expression by Optimized AAV6 Serotype Vectors In Vitro and in a Murine Xenograft Model In Vivo

We have observed that of the 10 AAV serotypes, AAV6 is the most efficient in transducing primary human hematopoietic stem cells (HSCs), and that the transduction efficiency can be further increased by specifically mutating single surface-exposed tyrosine (Y) residues on AAV6 capsids. In the present...

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Main Authors: Song, Liujiang, Li, Xiaomiao, Jayandharan, Giridhara R., Wang, Yuan, Aslanidi, George V., Ling, Chen, Zhong, Li, Gao, Guangping, Yoder, Mervin C., Ling, Changquan, Tan, Mengqun, Srivastava, Arun
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597592/
https://ncbi.nlm.nih.gov/pubmed/23516552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0058757
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