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Development of Optimized AAV Serotype Vectors for High-Efficiency Transduction at Further Reduced Doses

We have described the development of capsid-modified next-generation AAV vectors for both AAV2 and AAV3 serotypes, in which specific surface-exposed tyrosine (Y), serine (S), threonine (T), and lysine (K) residues on viral capsids were modified to achieve high-efficiency transduction at lower doses....

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Hum Gene Ther Methods
मुख्य लेखकों: Ling, Chen, Li, Baozheng, Ma, Wenqin, Srivastava, Arun
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Mary Ann Liebert, Inc. 2016
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4991608/
https://ncbi.nlm.nih.gov/pubmed/27431826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hgtb.2016.054
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