Optimizing the transduction efficiency of human hematopoietic stem cells using capsid-modified AAV6 vectors in vitro and in a xenograft mouse model in vivo

BACKGROUND: Although recombinant adeno-associated virus serotype 2 (AAV2) vectors have gained attention owing to their safety and efficacy in number of Phase I/II clinical trials, their transduction efficiency in hematopoietic stem cells (HSCs) has been reported to be low. Only a handful of addition...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Song, Liujiang, Kauss, M. Ariel, Kopin, Etana, Chandra, Manasa, Ul-Hasan, Taihra, Miller, Erin, Jayandharan, Giridhara R., Rivers, Angela E., Aslanidi, George V., Ling, Chen, Li, Baozheng, Ma, Wenqin, Li, Xiaomiao, Andino, Lourdes M., Zhong, Li, Tarantal, Alice F., Yoder, Mervin C., Wong, Kamehameha K., Tan, Mengqun, Chatterjee, Saswati, Srivastava, Arun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711144/
https://ncbi.nlm.nih.gov/pubmed/23830234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcyt.2013.04.003
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky