Optimization of the Capsid of Recombinant Adeno-Associated Virus 2 (AAV2) Vectors: The Final Threshold?

The ubiquitin-proteasome pathway plays a critical role in the intracellular trafficking of AAV2 vectors, and phosphorylation of certain surface-exposed amino acid residues on the capsid provides the primary signal for ubiquitination. Removal of several critical tyrosine (Y) and serine (S) residues o...

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Autors principals: Aslanidi, George V., Rivers, Angela E., Ortiz, Luis, Song, Liujiang, Ling, Chen, Govindasamy, Lakshmanan, Van Vliet, Kim, Tan, Mengqun, Agbandje-McKenna, Mavis, Srivastava, Arun
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3602601/
https://ncbi.nlm.nih.gov/pubmed/23527116
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059142
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