Enhanced Transduction of Human Hematopoietic Stem Cells by AAV6 Vectors: Implications in Gene Therapy and Genome Editing

We have reported that of the 10 most commonly used adeno-associated virus (AAV) serotype vectors, AAV6 is the most efficient in transducing primary human hematopoietic stem cells (HSCs) in vitro, as well as in vivo. More recently, polyvinyl alcohol (PVA), was reported to be a superior replacement fo...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Yang, Hua, Qing, Keyun, Keeler, Geoffrey D., Yin, Ling, Mietzsch, Mario, Ling, Chen, Hoffman, Brad E., Agbandje-McKenna, Mavis, Tan, Mengqun, Wang, Wei, Srivastava, Arun
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7150427/
https://ncbi.nlm.nih.gov/pubmed/32276210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.03.009
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