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An organometallic complex formed by an unconventional radical SAM enzyme
Pyrococcus horikoshii Dph2 (PhDph2) is an unusual radical SAM enzyme involved in the first step of diphthamide biosynthesis. It catalyzes the reaction by cleaving S-adenosylmethionine (SAM) to generate a 3-amino-3-carboxy propyl (ACP) radical. To probe the reaction mechanism, we synthesized a SAM an...
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| Publicado en: | J Am Chem Soc |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5068486/ https://ncbi.nlm.nih.gov/pubmed/27465315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.6b04155 |
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