Organometallic and radical intermediates reveal mechanism of diphthamide biosynthesis

Diphthamide biosynthesis involves a carbon-carbon bond forming reaction catalyzed by a radical S-adenosylmethionine (SAM) enzyme that cleaves a C-S bond in SAM to generate a 3-amino-3-carboxypropyl (ACP) radical. Using rapid freezing, we have captured an organometallic intermediate with an Fe-C bond...

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Publicat a:Science
Autors principals: Dong, Min, Kathiresan, Venkatesan, Fenwick, Michael K., Torelli, Andrew T., Zhang, Yang, Caranto, Jonathan D., Dzikovski, Boris, Sharma, Ajay, Lancaster, Kyle M., Freed, Jack H., Ealick, Steven E., Hoffman, Brian M., Lin, Hening
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6066404/
https://ncbi.nlm.nih.gov/pubmed/29590073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aao6595
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