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The asymmetric function of Dph1-Dph2 heterodimer in diphthamide biosynthesis

Diphthamide, the target of diphtheria toxin, is a post-translationally modified histidine residue found in archaeal and eukaryotic translation elongation factor 2 (EF2). In the first step of diphthamide biosynthesis, a [4Fe-4S] cluster-containing radical SAM enzyme, Dph1-Dph2 heterodimer in eukaryot...

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Bibliografski detalji
Izdano u:J Biol Inorg Chem
Glavni autori: Dong, Min, Dando, Emily E., Kotliar, Ilana, Su, Xiaoyang, Dzikovski, Boris, Freed, Jack H., Lin, Hening
Format: Artigo
Jezik:Inglês
Izdano: 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893874/
https://ncbi.nlm.nih.gov/pubmed/31463593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00775-019-01702-0
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