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Mechanistic understanding of Pyrococcus horikoshii Dph2, a [4Fe-4S] enzyme required for diphthamide biosynthesis

Diphthamide, the target of diphtheria toxin, is a unique posttranslational modification on eukaryotic and archaeal translation elongation factor 2 (EF2). The proposed biosynthesis of diphthamide involves three steps and we have recently found that in Pyrococcus horikoshii (P. horikoshii), the first...

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Bibliographische Detailangaben
Hauptverfasser: Zhu, Xuling, Dzikovski, Boris, Su, Xiaoyang, Freed, Jack H., Lin, Hening
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3066188/
https://ncbi.nlm.nih.gov/pubmed/20931132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c0mb00076k
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