Dph3 Enables Aerobic Diphthamide Biosynthesis by Donating One Iron Atom to Transform a [3Fe–4S] to a [4Fe–4S] Cluster in Dph1–Dph2

[Image: see text] All radical S-adenosylmethionine (radical-SAM) enzymes, including the noncanonical radical-SAM enzyme diphthamide biosynthetic enzyme Dph1–Dph2, require at least one [4Fe–4S](Cys)(3) cluster for activity. It is well-known in the radical-SAM enzyme community that the [4Fe–4S](Cys)(3...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Zhang, Yugang, Su, Dan, Dzikovski, Boris, Majer, Sean H., Coleman, Rachael, Chandrasekaran, Siddarth, Fenwick, Michael K., Crane, Brian R., Lancaster, Kyle M., Freed, Jack H., Lin, Hening
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2021
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8251694/
https://ncbi.nlm.nih.gov/pubmed/34154323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.1c03956
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