Profibrotic up-regulation of glucose transporter 1 by TGF-β involves activation of MEK and mammalian target of rapamycin complex 2 pathways

TGF-β plays a central role in the pathogenesis of fibroproliferative disorders. Defining the exact underlying molecular basis is therefore critical for the development of viable therapeutic strategies. Here, we show that expression of the facilitative glucose transporter 1 (GLUT1) is induced by TGF-...

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Bibliographic Details
Published in:FASEB J
Main Authors: Andrianifahanana, Mahefatiana, Hernandez, Danielle M., Yin, Xueqian, Kang, Jeong-Han, Jung, Mi-Yeon, Wang, Youli, Yi, Eunhee S., Roden, Anja C., Limper, Andrew H., Leof, Edward B.
Format: Artigo
Language:Inglês
Published: Federation of American Societies for Experimental Biology 2016
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5067255/
https://ncbi.nlm.nih.gov/pubmed/27480571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600428R
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