Fatty acid synthase is required for profibrotic TGF-β signaling

Evidence is provided that the fibroproliferative actions of TGF-β are dependent on a metabolic adaptation that sustains pathologic growth. Specifically, profibrotic TGF-β signaling is shown to require fatty acid synthase (FASN), an essential anabolic enzyme responsible for the de novo synthesis of f...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:FASEB J
Main Authors: Jung, Mi-Yeon, Kang, Jeong-Han, Hernandez, Danielle M., Yin, Xueqian, Andrianifahanana, Mahefatiana, Wang, Youli, Gonzalez-Guerrico, Anatilde, Limper, Andrew H., Lupu, Ruth, Leof, Edward B.
Format: Artigo
Sprog:Inglês
Udgivet: Federation of American Societies for Experimental Biology 2018
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998981/
https://ncbi.nlm.nih.gov/pubmed/29475397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701187R
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker