Fatty acid synthase is required for profibrotic TGF-β signaling

Evidence is provided that the fibroproliferative actions of TGF-β are dependent on a metabolic adaptation that sustains pathologic growth. Specifically, profibrotic TGF-β signaling is shown to require fatty acid synthase (FASN), an essential anabolic enzyme responsible for the de novo synthesis of f...

詳細記述

保存先:
書誌詳細
出版年:FASEB J
主要な著者: Jung, Mi-Yeon, Kang, Jeong-Han, Hernandez, Danielle M., Yin, Xueqian, Andrianifahanana, Mahefatiana, Wang, Youli, Gonzalez-Guerrico, Anatilde, Limper, Andrew H., Lupu, Ruth, Leof, Edward B.
フォーマット: Artigo
言語:Inglês
出版事項: Federation of American Societies for Experimental Biology 2018
主題:
Research
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5998981/
https://ncbi.nlm.nih.gov/pubmed/29475397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201701187R
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